Problem
Noise occurs when using a UR-C audio (UR22C, UR44C, UR816C) interface with a MacBook Pro (2016, 15inch) running macOS 10.12.
Background
This is a known macOS 10.12 issue that can occur with any USB 3.0 audio interface requiring a SuperSpeed (USB 3.1 Gen 1) connection.
Workaround
Use macOS 10.13 or later.